Stanozolol

Generic name: stanozolol (stah NO zo lall)
Brand name: Winstrol
Drug class: Androgens and anabolic steroids

What is stanozolol?

Stanozolol is a man-made steroid, similar to the a naturally occurring steroid testosterone.

Stanozolol is used in the treatment of hereditary angioedema, which causes episodes of swelling of the face, extremities, genitals, bowel wall, and throat. Stanozolol may decrease the frequency and severity of these attacks.

Stanozolol reduces bradykinin production and could potentially reduce the impact of a bradykinin storm. Bradykinin storms may be responsible for some of the complications experienced by COVID-19 patients.

Warnings

In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.

Before taking this medicine

Do not take stanozolol without first talking to your doctor if you have

• prostate cancer;

• breast cancer; or

• a high level of calcium in the blood (hypercalcemia).

To make sure stanozolol is safe for you, tell your doctor if you have ever had:

• heart or blood vessel disease;

• a heart attack;

• a high level of cholesterol in the blood;

• bleeding or blood clotting problems;

• diabetes;

• liver problems;

• kidney problems; or

• if you have taken an oral anticoagulant (blood thinner).

You may not be able to take stanozolol, or you may require a dosage adjustment or special monitoring during treatment.

Stanozolol is known to cause birth defects in an unborn baby. Do not take this medication if you are pregnant or could become pregnant during treatment.

It is not known whether stanozolol passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take stanozolol?

Take stanozolol exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

Take this medicine with a full glass of water.

Stanozolol can be taken with or without food.

It is important to take this medicine regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with this medicine to monitor progress and side effects.

Store at room temperature away from moisture, heat, and direct light.

Dosing information

Usual Adult Dose for Angioedema:

Prophylactic use to decrease freguency and severity of attacks of hereditary angioedema.

Initial dose: 2 mg orally 3 times a day.

Dose Adjustments:

Decrease dose at intervals of 1 to 3 months to a maintenance dose of 2 mg/day.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed, and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to threaten life. Contact an emergency room or poison control center for advice if an overdose is suspected.

Symptoms of an stanozolol overdose are not known.

What to avoid

There are no restrictions on food, beverages, or activities while taking stanozolol unless otherwise directed by your doctor.

Stanozolol side effects

In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.

If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• swelling of the arms or legs (especially ankles);

• frequent or persistent erections, or breast tenderness or enlargement (male patients); or

• voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients).

Common stanozolol side effects may include:

• new or worsening acne;

• difficulty sleeping;

• headache; or

• changes in sexual desire.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect stanozolol?

Before taking stanozolol, talk to your doctor if you are taking any of the following medicines:

• an anticoagulant (blood thinner) such as warfarin (Coumadin); or

• insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (DiaBeta, Glynase, Micronase), glimepiride (Amaryl), chlorpropamide (Diabinese), acetohexamide (Dymelor), tolbutamide (Orinase), tolazamide (Tolinase), and others.

You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with stanozolol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

What does my medication look like?

Stanozolol is available with a prescription under the brand name Winstrol. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Winstrol 2 mg-pink, round tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Stanozolol Side Effects

Cardiovascular
Cardiovascular effects may be precipitated in patients adversely affected by fluid retention. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy.

Genitourinary
Genitourinary effect following chronic administration and/or large dosages of anabolic steroids can result in oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop.

In female patients the use of anabolic steroids may result in virilization including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization.

Alterations in libido may occur (increased/decreased).

Hepatic
Life-threatening peliosis hepatis and hepatic abnormalities including hepatic neoplasms and hepatocellular carcinomas have occurred following prolonged therapy with high doses of anabolic steroids. Tumor regression did not occur in all cases following medication withdrawal.

Cholestatic hepatitis, jaundice, and abnormal liver function tests occur at relatively low doses.

Other
In female patients the use of anabolic steroids has resulted in virilization including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of stanozolol at signs of mild virilization may prevent irreversible virilization.

Musculoskeletal
Androgenic activity associated with anabolic steroids is involved in termination of linear bone growth by closure of the epiphyseal growth centers. Appropriate monitoring of bone age is recommended during stanozolol use in prepubertal patients.

Oncologic
Oncologic effects following prolonged therapy with large doses of anabolic steroids have included hepatic neoplasms and hepatocellular carcinomas.

Hematologic
Hematologic effects occurring during anabolic steroid therapy include alteration in clotting factors II, V, VII and X , prolonged prothrombin time (PT), and increased red cell production.

Endocrine
During exogenous administration of anabolic steroids, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). Large doses of exogenous anabolic steroids may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone (FSH).

Decreased glucose tolerance requiring adjustments in hyperglycemic control has occurred in diabetic patients during anabolic steroid therapy.

Metabolic
Metabolic effects occurring during anabolic steroid therapy in immobilized patients or those with metastatic breast disease include osteolytic-induced hypercalcemia.

Anabolic steroids effect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy.

The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred.

Renal
Anabolic steroids cause retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decrease urinary excretion of calcium. Patients should be instructed to report edema.

Gastrointestinal
Gastrointestinal effects occurring during stanozolol therapy include nausea and vomiting.